Anyone developing products - either desktop or net - needs to take Apple into account. Why?
Consider this: Apple's retail market share is 14 percent, and two-thirds for PCs costing $1,000 or more.
To make it short, nearly the entire demographic of computer users willing to spend non-trivial amounts of money are buying Macs. This is why I'm starting to see announcements of games being ported to the Mac, I think.
Couple that with the huge market share for Macs in universities, and you begin to understand why the Vista flop is a serious problem.