This is interesting - as of 2006, Monday Night Football is moving to ESPN. That's not the only change though - NBC is getting Sunday night football (which was ESPN's gig) - and they've got an interesting deal with the NFL on the games:
NBC will devote its entire Sunday night prime-time lineup to the NFL. The Sunday night games will start at 8:15 p.m. eastern and include flexible scheduling for the final seven weeks of the season, details of which will be developed by the league.
That issue has become more pressing since parity caused by the salary cap has resulted in teams moving up and down the standings annually, leaving bad teams that were strong the previous season in prime time and good teams that were bad the past season off of it.
So the schedule for the second half of the year will be up in the air, pending the ratings needs of a sponsor. I'm sure that will make coaching staffs happy. Will they do a one time adjustment at mid-year, or week by week?