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by Doug Thews.
Original Post: ASP.NET Apps/Domains Crash w/Anti-Virus Loaded
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Microsoft posted Knowledge Base Article 820746, which talks about how Web Applications & App Domains can restart because the anti-virus program changes the archive flag, or modification date. ASP.NET sees this, and restarts the affected app/domain because it thinks a critical file has been updated. This can lead to poor performance, since the app/domain has to be reconstructed after each restart.
The fix is only currently available through Microsoft Product Support Services, but hopefully will be included in a ASP.NET 1.0/1.1 Framework patch soon.