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I agree with Klaus that Smart Clients need another look, as ASP.NET is not the only solution for UI deployment.  The P&P book Smart Client Architecture and Design Guide came out in PDF form this week, and I have been reading this with great interest.  Take a look:

http://www.microsoft.com/downloads/details.aspx?FamilyId=8EC600BD-A2E5-44AC-9A8F-68D06361853E&displaylang=en

For myself, I can see several upcoming intranet projects that would better utilize Smart Clients than ASP.NET.  I am especially interested in ClickOnce and seeing how Code Access Security (CAS) will play a bigger part in developing secure applications.